Framework of Implicit Statistical Analysis applied to biochemical studies in animal nutrition and the representational viability of biochemical and physiological phenomena by implicative graphs
Visualizações: 32DOI:
https://doi.org/10.31416/rsdv.v13i2.1129Keywords:
S.I.A., Animal Nutrition, Metabolism, Pig Breeding, ZootechnyAbstract
The aim of this research was to verify the feasibility of using ASI on the same biochemical data as a study that used Anova and to test the hypothesis that ISA contributes to understanding biochemical processes through implicit graphs. The results showed that supplementation significantly increased the concentrations of essential biomolecules such as protein, fat and lactose, improving milk quality. The theoretical framework of the Implicit Statistical Analysis (ISA) was used as an innovative tool, revealing complex relationships between variables that traditional analyses would not capture. This methodologic framework allowed us to better understand the relations between high serum glutamine concentrations and increased lactose, as well as the impact of glutamate on sow milk fat synthesis. Implicit graphs have the potential to create graphical representations of biochemical reactions and physiological processes.
References
ASI – Analyse Statistique Implicative Références bibliographiques sur l'Analyse Statistique Implicative https://sites.univ-lyon2.fr/asi/ref/refasi. 2024.
BELFIORE, F.; ZANELLO, S. Fatty acid synthesis from glutamate in the adipose tissue of normal subjects and obese patients – Na enzyme study. Biochemistry Molecular Medicine, v. 54, p. 19-28, 1995. DOI: https://doi.org/10.1006/bmme.1995.1003
CURI, R.; LAGRANHA, C. J.; DOI, S. Q.; SELLITTI, D. F.; PROCOPIO, J.; PITHON-CURI, T. C.; CORLESS, M.; NEWSHOLME, P. Molecular Mechanisms of glutamine action. Journal of Cellular Physiology, v. 204, p. 392-401, 2005. DOI: https://doi.org/10.1002/jcp.20339
CURTHOYS, N. P.; WATFORD, M. Regulation of glutaminase activity and glutamine metabolism. Annual Review of Nutrition, v. 15, p. 133-159, 1995. DOI: https://doi.org/10.1146/annurev.nu.15.070195.001025
FILIPP, F. V.; SCOTT, D. A.; RONAI, Z. A.; OSTERMAN, A. L.; SMITH, J. W. Reverse TCA cycle flux through isocitrate dehydrogenase 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Research, v. 25, p. 375-383, 2012.
METALLO, C. M.; GAMEIRO, P. A.; BELL, E. L.; MATTANI, K. R.; YANG, J.; HILLER, K.; JEWELL, C. M.; JOHNSON, Z. R.; IRVINE, D. J. et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature, v. 481, p. 380-384, 2011. DOI: https://doi.org/10.1038/nature10602
MULLEN, A. R.; WEATON, W. W.; JIN, E. S. et al. Reductive carboxylation supports growth in tumor cells with defective mitochondria. Nature, v. 481, p. 385-388, 2011. DOI: https://doi.org/10.1038/nature10642
NEWSHOLME, P. Why is L-glutamine metabolism important to cells of the immune system in health, post injury, surgery or infection? Journal of Nutrition, v. 131, p. 2515S-2522S, 2001. DOI: https://doi.org/10.1093/jn/131.9.2515S
RÉGNIER, J. C.; ANDRADE, V. L. V. X. Análise Estatística Implicativa e Análise de Similaridade no Quadro Teórico e Metodológico das Pesquisas em Ensino de Ciências e Matemática com a utilização do Software CHIC. 1. ed. Recife: EDUFRPE, 2020.
SANTOS DE AQUINO, R.; CARNEIRO-LEÃO, A. M. A.; ACIOLY-RÉGNIER, N. M.; ANDRADE, V. L. V. X.; RÉGNIER, J.-C. Análise estatística implicativa e análise de Variância: estudo estatístico comparativo sobre o desempenho escolar em sala de aula multicultural, p. 169-189, 2021. In: Analyse statistique implicative: analyses quali-quantitatives des liens orientes entre variables e/ou groupes de variables. Eds. RÉGNIER, J.-C.; GRAS, R.; BODIN, A.; COUTURIER, R.; VERGNAUD, G. Université Bourgogne Franche-Comté, Bensançon, France. ISBN: 978-2-9562045-5-8. 2021.
SANTOS DE AQUINO, R.; DUTRA, W. M.; MANSO, H. E. C. C.; KUTSCHENKO, M.; NOGUEIRA, E. T.; WATFORD, M. Glutamine and glutamate (AminoGut) supplementation influences sow colostrum and mature milk composition. Livestock Science, 2014. DOI: http://dx.doi.org/10.1016/j.livsci.2014.07.009
WATFORD, M. Glutamine and glutamate: nonessential or essential amino acids? Animal Nutrition, v. 1, p. 119-122, 2015. DOI: http://dx.doi.org/10.1016/j.aninu.2015.08.008
XIAO, Y. P.; LI, X. Y.; WU, T. X.; YANG, Q. H.; YANG, C. M.; CHEN, A. G. Effects of dietary glutamine supplementation on nutrient absorption and activity of enzymes involved in glutamine metabolism and energy production in the jejunum of weaned piglets. Journal of Animal and Veterinaria Advanced, v. 11, p. 1441-1449, 2012a.
XIAO, Y. P.; WU, T. X.; HONG, Q. H.; SUN, J. M.; CHEN, A. G.; YANG, C. M.; LI, X. Y. Response to weaning and dietary L-glutamine supplementation: metabolomics analysis in piglets by gas chromatography/mass spectrometry. Biomedicine and Biotechnology, v. 13, p. 567-578, 2012b.
YOO, H.; ANTONIEWICZ, M. R.; STEPHANOPOULOS, G.; KELLEHER, J. K. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. Journal of Biologic Chemistry, v. 283, p. 20621-20627, 2008.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Revista Semiárido De Visu

This work is licensed under a Creative Commons Attribution 4.0 International License.